Growth Cones of Human Fetal Axons Proteins and for Viral Exocytosis from Transport of Tegument and Envelope Secretory Vesicle Pathway for Anterograde Herpes Simplex Virus Utilizes the Large
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چکیده
Published Ahead of Print 28 January 2009. 2009, 83(7):3187. DOI: 10.1128/JVI.01579-08. J. Virol. Diefenbach and Anthony L. Cunningham Aggarwal, Bibing Tijono, Frazer J. Rixon, Russell J. Monica Miranda-Saksena, Ross A. Boadle, Anupriya Growth Cones of Human Fetal Axons Proteins and for Viral Exocytosis from Transport of Tegument and Envelope Secretory Vesicle Pathway for Anterograde Herpes Simplex Virus Utilizes the Large
منابع مشابه
Herpes simplex virus utilizes the large secretory vesicle pathway for anterograde transport of tegument and envelope proteins and for viral exocytosis from growth cones of human fetal axons.
Axonal transport of herpes simplex virus (HSV-1) is essential for viral infection and spread in the peripheral nervous system of the host. Therefore, the virus probably utilizes existing active transport and targeting mechanisms in neurons for virus assembly and spread from neurons to skin. In the present study, we used transmission immunoelectron microscopy to investigate the nature and origin...
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The mechanism of anterograde transport of alphaherpesviruses in axons remains controversial. This study examined the transport, assembly, and egress of herpes simplex virus type 1 (HSV-1) in mid- and distal axons of infected explanted human fetal dorsal root ganglia using confocal microscopy and transmission electron microscopy (TEM) at 19, 24, and 48 h postinfection (p.i.). Confocal-microscopy...
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Herpes simplex virus (HSV) reactivates from latency in the neurons of dorsal root ganglia (DRG) and is subsequently transported anterogradely along the axon to be shed at the skin or mucosa. Although we have previously shown that only unenveloped nucleocapsids are present in axons during anterograde transport, the mode of transport of tegument proteins and glycoproteins is not known. We used a ...
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